There are a few scenarios where running a reconfirmation campaign is advisable: 1. Low Engagement: If you notice a significant drop in your open or click-through rates, it may be time to reconfirm your subscribers. 2. List Hygiene: Periodically, to maintain a clean and engaged list. 3. Regulatory Compliance: When new regulations are introduced, or you update your privacy policies. 4. Before a Major Campaign: To ensure that your list is primed and ready for an upcoming major campaign or announcement.