Follow these steps to effectively conduct layout testing: 1. Define Your Goals: Decide what you want to achieve, whether it's higher open rates, click-through rates, or another metric. 2. Segment Your Audience: Divide your email list into smaller segments to test different layouts with similar audience demographics. 3. Create Variations: Develop multiple versions of your email with different layouts. 4. Use A/B Testing: Send different versions to different segments of your audience to compare performance. 5. Analyze Results: Use analytics tools to measure the effectiveness of each layout. 6. Make Data-Driven Decisions: Based on the results, choose the layout that performs the best and implement it in your future email campaigns.