To maximize the effectiveness of email marketing, startups should follow these best practices: - Consistency: Send emails regularly but avoid overwhelming your subscribers. - Compliance: Adhere to email marketing laws like the CAN-SPAM Act and GDPR. - A/B Testing: Test different elements like subject lines and CTAs to optimize performance. - Analytics: Regularly review campaign data to make informed decisions. - Feedback: Encourage and act on subscriber feedback to improve your campaigns.