Respecting opt-out requests is essential for several reasons. Firstly, it helps maintain a positive brand reputation. Ignoring such requests can lead to dissatisfaction and negative word-of-mouth. Secondly, it's legally required under regulations like the CAN-SPAM Act and GDPR. Non-compliance can result in fines and legal actions. Lastly, it improves email deliverability and engagement rates by ensuring that only interested recipients receive your emails.